Evidence-based nursing practice about risk of adverse drug interaction in icu – systematic review

Cassia Amorim Rodrigues Araújo, Isabel Cristina Fonseca da Cruz


Abstract: This study analyzed the risks of adverse drug interactions based on updated scientific evidence, through the intensive care team, within a maximum of 7 days of hospitalization. Methods: This is a systematic review of the literature through the search for online data from 2012 to 2019. Through evidence-based practices on adverse drug interactions in intensive care units, using a PICOT strategy. Results: 10 publications were analyzed using the thematic analysis technique, in which 2 categories emerged: Risk of drug interactions associated with the number of drugs prescribed, highlighting the high number of medications administered simultaneously and the importance of the multidisciplinary team for patient safety linked to the need for professional updating and effective communication between the group. Conclusion: The identification of a significant number of drug interactions stands out in the highly complex patient, and this number increases when it comes to the adult / elderly person due to the number of drugs already pre-existing in their therapy. Current evidence addresses that communication between the multidisciplinary team, coupled with the installation of protocols, flowcharts and rescheduling of medications can be a facilitating component for patient safety, preventing adverse events.
Keywords: Drug interactions; Intensive Care Units; Patient safety; Nursing care.


Heart failure, nursing diagnosis; nursing care; critical specialized nursing; watch out; nursing

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URN: http://www.jsncare.uff.br/index.php/jsncareurn:nbn:de:1983-4152jsncare.v13i1.33786

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